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KMID : 0369820000300020085
Jorunal of Korean Pharmaceutical Sciences
2000 Volume.30 No. 2 p.85 ~ p.91
Statistical Consideration on the Similarity in Dissolution Profile of Two Fast Releasing Tablets
Á¶Á¤È¯/Cho JH
À̼¼Èñ/±èÈñ¼±/¿À½Â¿­/Lee SH/Kim HS/Oh SY
Abstract
We have studied the dissolution kinetics of two fast releasing tablets in four media, and the similarity of dissolution profiles was compared using 3 methods. Two of the methods were introduced from statistical algorithm of distance methods, which are maximum distance and Mahalanobis distance. The dissolution kinetics were also analysed using FDA method for similarity evaluation, and the results were compared with those obtained using the distance methods.
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